POP Biotechnologies and EuBiologics’ EuCorVac-19 COVID-19 Vaccine Hits Target in Phase 3 Trial

POP Biotechnologies and EuBiologics’ EuCorVac-19 COVID-19 Vaccine Hits Target in Phase 3 Trial

July 14, 2023 Editor 0

POP Biotechnologies and EuBiologics’ EuCorVac-19 COVID-19 Vaccine Hits Target in Phase 3 TrialPOP Biotechnologies and EuBiologics’ EuCorVac-19 COVID-19 Vaccine Hits Target in Phase 3 Trial

POP Biotechnologies and EuBiologics’ EuCorVac-19 COVID-19 Vaccine Hits Target in Phase 3 Trial
EuCorVac-19
EuCorVac-19, a recombinant protein vaccine displaying the SARS-CoV-2 receptor-binding domain (RBD) antigen on the immunogenic liposomes


BUFFALO, N.Y., July 14, 2023 (Newswire.com)
–
 POP Biotechnologies (POP BIO), a Buffalo, NY-based biopharmaceutical startup, announces top line interim results of a Phase 3 clinical trial of EuCorVac-19, a COVID-19 vaccine candidate being developed by South Korean partner EuBiologics (KOSDAQ: 206650). EuCorVac-19 is a protein-based vaccine consisting of a vaccine antigen displayed on immunogenic nanoparticles, using POP BIO’s spontaneous-nanoliposome antigen particle (SNAP) technology.

The phase 3 trial of EuCorVac-19 was conducted in the Philippines in approximately 2,600 adults (NCT05572879). EuCorVac-19 demonstrated superior antibody immunogenicity compared to a World Health Organization Emergency Use Authorized adenoviral vector vaccine, thereby meeting the primary endpoint of the phase 3 trial.

The formation of neutralizing antibodies, which prevent COVID-19 infection, was more than twice as high in EuCorVac-19 compared to the control vaccine. EuCorVac-19 exhibited a high serological response rate with neutralizing antibody titers increasing after vaccination. In particular, the neutralizing antibody titers and serum response rates in subjects aged over 65 exceeded those of the control vaccine. In immunogenicity analysis against the Omicron BA.5 strain, EuCorVac-19 induced more than twice the neutralizing antibody titer compared to the control vaccine.

EuCorVac-19’s safety profile was further established in this phase 3 study. EuCorVac-19 showed a slightly lower incidence than the control vaccine of solicited adverse events and there was no difference between EuCorVac-19 and the control vaccine in the incidence of unsolicited adverse events.

These results further validate the strength and synergy of POP BIO’s SNAP and EuBiologics’ EuIMT platform technologies used in the EuCorVac-19 vaccine. Further development of booster vaccines, new strain vaccines, and combination vaccines for COVID-19 will be significantly more straightforward in the future. 

“Achieving the completion of this Phase III trial is an enormous milestone for our technologies. These results provide validation towards not only solving this unprecedented global crisis but also provides invaluable support towards our platform’s development, further enabling the creation of new vaccines with tremendous potential to alleviate suffering worldwide,” said POP BIO co-founder Jonathan Smyth.

EuCorVac-19 was already shown to be safe and immunogenic in a Phase I/II clinical trial, the results of which were announced in December 2021. The Philippine Phase 3 trial, conducted since third quarter of 2022, were supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the ministry of Health & Welfare, Republic of Korea.

Based on the results of this clinical study, EuBiologics plans to apply for product approval in the Philippines shortly. Later this year, results will become available from a second independent Phase 3 clinical study being carried out in the Democratic Republic of Congo.

About POP Biotechnologies: POP Biotechnologies, Inc. is a privately held biotechnology company focused on the research and development of novel therapeutics and vaccines employing their proprietary porphyrin-phospholipid (PoP) liposome technologies. The PoP technology, exclusively licensed from the State University of New York Research Foundation (SUNY-RF), was developed by company co-founder Dr. Jonathan Lovell at his academic facilities at The State University of New York at Buffalo (SUNY Buffalo). POP Biotechnologies is currently a resident of the SUNY Buffalo incubator at Baird Research Park.

About POP BIO’s SNAP Technology: POP BIO’s Spontaneous Nanoliposome Antigen Particleization (SNAP) technology enables the rapid development and manufacturing of highly immunogenic particle-based vaccines and immunotherapies directed against infectious disease and cancer through the use of a cobalt modified variant of the PoP technology (CoPoP). The SNAP technology enables the seamless generation of stable particle-formation and liposome-display of protein and peptide antigens resulting in substantial improvements in immune responses.

About EuBiologics: EuBiologics is a South Korean Biotechnology company that is advancing the EuCorVac-19 COVID-19 vaccine and other vaccine products. EuBiologics has two main animal-based bioreactors (1,000L) to produce recombinant protein antigens at Chuncheon Plant 1(C-Plant) and EcML(Monophosphoryl Lipid A) which is adjuvant at Chuncheon Plant 2(V-Plant). The total capacity of the COVID-19 vaccine is currently in the hundreds of millions of doses per year.

About EuBiologics’ EuIMT Technology: EuBioloigcs’ Immune Modulation Technology using genetically engineered Monophosphoryl Lipid A (MLA), called EcML that is a unique TLR4 agonist. EuBiologics has IP protection around EcML and various adjuvant systems including EcML. Eubiologics’ EcML and POP BIO’s SNAP technologies synergize to create ultrapotent next-generation vaccines.

Contact Information:

Jonathan Smyth

President

[email protected]

+13152200087

Original Source:

POP Biotechnologies and EuBiologics’ EuCorVac-19 COVID-19 Vaccine Hits Target in Phase 3 Trial

Whittier Street Health Center’s 24th Annual Men’s Health Summit a Triumph

Whittier Street Health Center’s 24th Annual Men’s Health Summit a Triumph

July 14, 2023 Editor 0

Whittier Street Health Center’s 24th Annual Men’s Health Summit a TriumphWhittier Street Health Center’s 24th Annual Men’s Health Summit a Triumph

Whittier Street Health Center’s 24th Annual Men’s Health Summit a Triumph
Men’s Health Honorees
William Watkins, Rev. John Finley, David Morales, Leverett Wing, Frederica M Williams, Jean Prezeau


BOSTON, July 14, 2023 (Newswire.com)
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Whittier Street Health Center, a community health center with a mission to serve as a center of excellence that provides high quality and accessible health care and social services that achieve health equity, social justice, and the economic well-being of a diverse patient population, is thrilled to announce that its 24th Annual Men’s Health Summit held June 24 at the Frederica M. Williams Building, 1290 Tremont Street, Roxbury, was a tremendous success with an estimated 150 community leaders and residents in attendance.

The theme at this year’s summit, “UNITED for Men’s Health: Grounded in Equity,” prompted open and engaging discussion on how, across the country, gaps and disparities in health care continue to increase and persist. 

The annual event included a health fair, health screenings, and a panel discussion and conversation about men’s health and wellness. A highlight of the Summit was the presentation of this year’s Men’s Health Champion Awards to the following:

  • Mr. Wilner Auguste, founder, Haitian American United (HAU), Mattapan;
  • Rev. John Finley, co-founder and head of Epiphany School, Dorchester; 
  • Rev. Art Gordon, pastor, St. John Missionary Baptist Church, Roxbury; 
  • Mr. David Morales, general manager, UniCare, Lynn (formerly of Lynnfield); 
  • Mr. Jean Prezeau, men’s health ambassador, Whitter Street Health Center, Roxbury; 
  • Mr. William Watkins, MBA, vice president of digital strategies and partnerships, Urban League of Eastern Massachusetts, Roxbury; and 
  • Mr. Leverett Wing, president and CEO, Commonwealth Seminar, Chelsea and Boston.

Serving as guest speaker was NBC10 News Anchor Glenn Jones.

The Annual Men’s Health Summit aligns with Whittier Street Health Center’s mission to serve as a center of excellence that provides high-quality, and accessible health care and social services that achieve health equity, social justice, and the economic well-being of our diverse populations. 

“Open, honest, and genuine discussions were once again a high point of this year’s Men’s Health Summit,” said Frederica M. Williams, president and CEO of Whittier Street Health Center. “This important annual event aims to shine a light on and help to address preventable causes that contribute to increased morbidity and mortality rates, and decreased life expectancy for men, and in particular those of color.”

About Whittier Street Health Center

Whittier Street Health Center is an independently licensed community health care center with a mission of providing high-quality, reliable and accessible primary healthcare for diverse populations while promoting wellness and eliminating health and social disparities. A champion of equitable access to high-quality, patient-focused care, social justice and economic equity, Whittier Street Health Center serves more than 30,000 patients and 20,000 community outreach visits annually; its ethnically and racially diverse patient base is primarily made up of individuals from Roxbury, Dorchester, Jamaica Plain, the South End and greater Boston. For more information, please visit www.wshc.org as well as Facebook (www.facebook.com/WhittierStreetHealthCenter), Twitter (@Whittier_Boston), or LinkedIn (https://www.linkedin.com/company/whittier-street-health-center), or call 617-989-3221.

Contact Information:

Nicole Hales

President, PRfirst

[email protected]

617-947-7983

Frederica Williams

President & CEO

[email protected]

617-989-3221

Original Source:

Whittier Street Health Center’s 24th Annual Men’s Health Summit a Triumph

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July 14, 2023 admin 0

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